4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:443642-40-8
Molecular Formula:C₁₂H₁₅ClN₄O₄
Molecular Weight:314.728
Hs Code.:
Mol file:443642-40-8.mol

Synonyms:2'-C-methyl-6-chloro-7-deazaguanosine;2-amino-4-chloro-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine;2-amino4-chloro-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine;7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE,4-CHLORO-7-(2-C-METHYL-B-D-RIBOFURANOSYL)-;(2R,3R,4R,5R)-2-(2-Amino-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol;

Suppliers and Price of 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

PSA：126.65000
LogP:0.24970

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 9 articles about 4-Chloro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 443642-39-5
2-amino-4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

: 443642-40-8
2-amino-4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With boron trichloride; In dichloromethane; at -78 - -20 ℃; for 4.5h;
DOI:10.1021/jm040068f

Reference yield:

: 443642-31-7
(2S,3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-ol

: 443642-40-8
2-amino-4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: HBr; AcOH / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 0.65 g / KOH; tris[2-(2-methoxyethoxy)ethyl]amine / acetonitrile / 1 h / 20 °C

3: 84 percent / boron trichloridei122 / CH₂Cl₂ / 4.5 h / -78 - -20 °C

With potassium hydroxide; Tris(3,6-dioxaheptyl)amine; hydrogen bromide; boron trichloride; acetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm040068f

Reference yield:

: 168427-35-8
(3R,4S,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxytetrahydrofuran-3-ol

: 443642-40-8
2-amino-4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 72 h / 20 °C

2: 16.7 g / diethyl ether / 7 h / -30 - -15 °C

3: HBr; AcOH / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.65 g / KOH; tris[2-(2-methoxyethoxy)ethyl]amine / acetonitrile / 1 h / 20 °C

5: 84 percent / boron trichloridei122 / CH₂Cl₂ / 4.5 h / -78 - -20 °C

With potassium hydroxide; Tris(3,6-dioxaheptyl)amine; hydrogen bromide; boron trichloride; Dess-Martin periodane; acetic acid; In diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm040068f