9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one

Base Information

• Chemical Name: 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one
• CAS No.: 98983-40-5
• Molecular Formula: C₁₀H₁₁FN₄O₄
• Molecular Weight: 270.22
• Mol file: 98983-40-5.mol

Synonyms:6H-Purin-6-one, 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1,9-dihydro-;9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one;

Chemical Property of 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.81
• Boiling Point: 744.8 °C at 760 mmHg
• Flash Point: 404.24 °C
• PSA: 113.26000
• Density: 2.01g/cm³
• LogP: -1.29170

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one

There total 7 articles about 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-(2-Deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)-1-benzylinosine (136852-40-9) → 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)hypoxanthine (98983-40-5)

Guidance literature:

With trifluoroacetic acid; In chloroform; Ambient temperature;

DOI:10.1021/jo00028a030

Reference yield:

2-deoxy-2-fluoro-α,β-D-arabinofuranose 1-phosphate + hypoxanthine (68-94-0) → 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)hypoxanthine (98983-40-5)

Guidance literature:

With recombinant E_.coli purine nucleoside phosphorylase; In water; at 52 ℃; for 96h; Enzymatic reaction;

DOI:10.3762/bjoc.10.173

Reference yield:

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (20187-82-0,20227-41-2,64183-27-3,123334-75-8) → 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)hypoxanthine (98983-40-5)

Guidance literature:

With sodium nitrite; In acetic acid; for 48h; Yield given;

DOI:10.1248/cpb.37.336

upstream raw materials:

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine

9-(2-Deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)-1-benzylinosine

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide

9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N⁶-benzoyladenine