ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

Base Information

Chemical Name:ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate
CAS No.:1335140-03-8
Molecular Formula:C₂₅H₄₁N₃O₄
Molecular Weight:447.618
Hs Code.:

Synonyms:ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

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Chemical Property of ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

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Technology Process of ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

There total 15 articles about ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₄₅N₃O₇S

: 1335140-03-8
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

Reference yield:

: 63987-70-2
ethyl 3-benzylamino-2-ethylpropanoate

: 1335140-03-8
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 4 h

2.1: ethanol

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: -78 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

5.1: dimethyl sulfoxide; triethylamine; oxalyl dichloride / dichloromethane / -78 - 0 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 3 h / -78 °C

7.1: triethylamine / dichloromethane / 3 h / 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; 5.1: |Swern Oxidation;

Reference yield:

: 1335139-40-6
tert-butyl (2-formylbutyl)carbamate

: 1335140-03-8
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 3 h / -78 °C

2.1: triethylamine / dichloromethane / 3 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;