ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Base Information

Chemical Name:ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate
CAS No.:1335144-18-7
Molecular Formula:C₂₅H₄₃N₃O₄
Molecular Weight:449.634
Hs Code.:

Synonyms:ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Suppliers and Price of ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

There total 16 articles about ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335140-03-8
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hex-2-enoate

: 1335144-18-7
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Guidance literature:: With palladium 10% on activated carbon; water; hydrogen; In ethanol; for 13h;

Reference yield:

: 3070-65-3
ethyl 2-methylenebutyrate

: 1335144-18-7
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: ethanol / 17 h / 70 °C

2.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 4 h

3.1: ethanol

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: -78 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

6.1: dimethyl sulfoxide; triethylamine; oxalyl dichloride / dichloromethane / -78 - 0 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 3 h / -78 °C

8.1: triethylamine / dichloromethane / 3 h / 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

10.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 13 h

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; 6.1: |Swern Oxidation;

Reference yield:

: 63987-70-2
ethyl 3-benzylamino-2-ethylpropanoate

: 1335144-18-7
ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 4 h

2.1: ethanol

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: -78 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

5.1: dimethyl sulfoxide; triethylamine; oxalyl dichloride / dichloromethane / -78 - 0 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 3 h / -78 °C

7.1: triethylamine / dichloromethane / 3 h / 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

9.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 13 h

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; 5.1: |Swern Oxidation;