4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride

Base Information

• Chemical Name: 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride
• CAS No.: 1335140-06-1
• Molecular Formula: C₁₈H₃₁N₃O₂*ClH
• Molecular Weight: 357.924
• Mol file: 1335140-06-1.mol

Synonyms:4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride

Chemical Property of 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride

There total 17 articles about 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-{[(tert-butoxycarbonyl)amino]methyl}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoate (1335144-18-7) → 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride (1335140-06-1)

Guidance literature:

With hydrogenchloride; water; for 5h; Reflux;

Reference yield:

ethyl 2-methylenebutyrate (3070-65-3) → 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride (1335140-06-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: ethanol / 17 h / 70 °C

2.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 4 h

3.1: ethanol

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: -78 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

6.1: dimethyl sulfoxide; triethylamine; oxalyl dichloride / dichloromethane / -78 - 0 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 3 h / -78 °C

8.1: triethylamine / dichloromethane / 3 h / 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

10.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 13 h

11.1: water; hydrogenchloride / 5 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; 6.1: |Swern Oxidation;

Reference yield:

ethyl 3-benzylamino-2-ethylpropanoate (63987-70-2) → 4-(aminomethyl)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}hexanoic acid hydrochloride (1335140-06-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 4 h

2.1: ethanol

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: -78 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

5.1: dimethyl sulfoxide; triethylamine; oxalyl dichloride / dichloromethane / -78 - 0 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 3 h / -78 °C

7.1: triethylamine / dichloromethane / 3 h / 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C

9.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 13 h

10.1: water; hydrogenchloride / 5 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; 5.1: |Swern Oxidation;

upstream raw materials:

tert-butyl (2-formylbutyl)carbamate

ethyl 2-methylenebutyrate

ethyl 3-benzylamino-2-ethylpropanoate

ethyl 2-{[(tert-butoxycarbonyl)amino]methyl}butyrate