ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

Base Information

Chemical Name:ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate
CAS No.:1322757-78-7
Molecular Formula:C₁₈H₁₉ClN₂O₂S
Molecular Weight:362.88
Hs Code.:

Synonyms:ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

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Chemical Property of ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

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Technology Process of ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

There total 4 articles about ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1322757-73-2
ethyl 5-amino-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylate

: 75-03-6
ethyl iodide

: 1322757-78-7
ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/ejoc.201100215

Reference yield:

: 882278-95-7
C₁₇H₁₆ClNO₂S₂

: 1322757-78-7
ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: palladium on carbon; hydrogen / ethanol / 0.08 h

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With sodium azide; palladium on carbon; hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100215

Reference yield:

: 1322757-80-1
ethyl 5-azido-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylate

: 1322757-78-7
ethyl 3-(4-chlorophenyl)-4-cyano-5-(diethylamino)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / ethanol / 0.08 h

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With palladium on carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201100215