N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

Base Information

Chemical Name:N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide
CAS No.:1374962-30-7
Molecular Formula:C₃₃H₃₉N₅O₆S
Molecular Weight:633.769
Hs Code.:

Synonyms:N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

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Chemical Property of N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

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Technology Process of N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

There total 6 articles about N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1308992-50-8,1374962-72-7
N-benzenesulfonyl-D-leucine

: C₂₁H₂₄N₄O₃*(x)ClH

: 1374962-30-7
N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5.33333h; Inert atmosphere;

Reference yield:

: 172349-26-7
C₂₆H₃₂N₄O₅

: 1374962-30-7
N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; isopropyl alcohol / ethyl acetate / Cooling

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; In dichloromethane; ethyl acetate;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1374962-30-7
N-benzenesulfonyl-D-leucyl-L-prolyl-{[4-(N-benzyloxycarbonyl)amidinophenyl]methyl} amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 4 h / 0 - 20 °C / pH 9 - 10

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane;