methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Base Information

Chemical Name:methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate
CAS No.:574746-58-0
Molecular Formula:C₂₅H₂₆ClNO₄
Molecular Weight:439.939
Hs Code.:

Synonyms:methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Suppliers and Price of methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

There total 4 articles about methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 100-46-9
benzylamine

: 515160-07-3
methyl 3-(2-benzyloxy-3-chlorophenyl)-3-hydroxy-2-methylenepropanoate

: 574746-58-0
methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Guidance literature:: In methanol; for 72h;
DOI:10.1081/SCC-120018937

Reference yield:

: 38544-16-0
2-(benzyloxy)-5-chlorobenzaldehyde

: 574746-58-0
methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 1,4-diazabicyclo[2.2.2]octane / CDCl₃ / 504000 h

2: 69 percent / methanol / 72 h

With 1,4-diaza-bicyclo[2.2.2]octane; In methanol; chloroform-d1; 1: Baylis-Hillman reaction;
DOI:10.1081/SCC-120018937

Reference yield:

: 100-39-0
benzyl bromide

: 574746-58-0
methyl 2-(benzylaminomethyl)-3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / K₂CO₃; NaI / acetone / 12 h / Heating

2: 78 percent / 1,4-diazabicyclo[2.2.2]octane / CDCl₃ / 504000 h

3: 69 percent / methanol / 72 h

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; sodium iodide; In methanol; chloroform-d1; acetone; 2: Baylis-Hillman reaction;
DOI:10.1081/SCC-120018937