5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

Base Information

Chemical Name:5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde
CAS No.:1267606-11-0
Molecular Formula:C₄₄H₅₁NO₃SSi
Molecular Weight:702.045
Hs Code.:

Synonyms:5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

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Chemical Property of 5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

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Technology Process of 5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

There total 8 articles about 5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.6%

: 1267606-10-9
[3-benzyloxy-4-(2-thiophene-2-ylvinyl)phenyl]butyl[4-(tert-butyldiphenylsiloxy) butyl]amine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1267606-11-0
5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: [3-benzyloxy-4-(2-thiophene-2-ylvinyl)phenyl]butyl[4-(tert-butyldiphenylsiloxy) butyl]amine; With n-butyllithium; In tetrahydrofuran; hexane; at -72 - -66 ℃; for 0.583333h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -72 - -10 ℃; for 1.5h; Inert atmosphere;

With water; In tetrahydrofuran; hexane; at -10 ℃;

Reference yield:

: 4543-95-7
N-butyl-4-hydroxybutan-1-amine

: 1267606-11-0
5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hexamethylsilazane / 1,4-dioxane / 22 h / 100 °C

2.1: 1 h / 80 °C

3.1: trichlorophosphate / 1.13 h / Cooling with ice

3.2: 1.5 h / 50 - 70 °C

4.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere

6.2: 2.13 h / Cooling with ice; Inert atmosphere

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

7.2: 1.5 h / -72 - -10 °C / Inert atmosphere

7.3: -10 °C

With 1H-imidazole; n-butyllithium; water; potassium hexamethylsilazane; phenyllithium; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1267606-02-9
4-[(3-benzyloxyphenyl)butylamino]butyl acetate

: 1267606-11-0
5-[2-[2-benzyloxy-4-[butyl[4-(tert-butyldiphenylsiloxy) butyl]amino]phenyl]vinyl]thiophene-2-carboaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 1.13 h / Cooling with ice

1.2: 1.5 h / 50 - 70 °C

2.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere

4.2: 2.13 h / Cooling with ice; Inert atmosphere

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

5.2: 1.5 h / -72 - -10 °C / Inert atmosphere

5.3: -10 °C

With 1H-imidazole; n-butyllithium; water; phenyllithium; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide;