2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Base Information

Chemical Name:2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile
CAS No.:1267606-15-4
Molecular Formula:C₃₉H₄₀N₄O₃S
Molecular Weight:644.838
Hs Code.:

2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Synonyms:2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

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Chemical Property of 2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

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Technology Process of 2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

There total 9 articles about 2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.4%

: 1267606-12-1
5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-carboaldehyde

: 171082-32-9
2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran

: 1267606-15-4
2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Guidance literature:: With ammonium acetate; In tetrahydrofuran; ethanol; at 20 ℃; for 1.5h;

Reference yield:

: 53087-13-1
3-(benzyloxy)phenyl bromide

: 1267606-15-4
2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hexamethylsilazane / 1,4-dioxane / 22 h / 100 °C

2.1: 1 h / 80 °C

3.1: trichlorophosphate / 1.13 h / Cooling with ice

3.2: 1.5 h / 50 - 70 °C

4.1: sodium hydroxide; water / ethanol / 0.5 h / 20 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: phenyllithium / dibutyl ether; tetrahydrofuran / 0.25 h / Cooling with ice; Inert atmosphere

6.2: 2.13 h / Cooling with ice; Inert atmosphere

7.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

7.2: 1.5 h / -72 - -10 °C / Inert atmosphere

7.3: -10 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

9.1: ammonium acetate / ethanol; tetrahydrofuran / 1.5 h / 20 °C

With 1H-imidazole; n-butyllithium; ammonium acetate; tetrabutyl ammonium fluoride; water; potassium hexamethylsilazane; phenyllithium; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1267606-10-9
[3-benzyloxy-4-(2-thiophene-2-ylvinyl)phenyl]butyl[4-(tert-butyldiphenylsiloxy) butyl]amine

: 1267606-15-4
2-[4-[2-[5-[2-[2-benzyloxy-4-[butyl(4-hydroxybutyl)amino]phenyl]vinyl]thiophene-2-yl]vinyl]-3-cyano-5,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -72 - -66 °C / Inert atmosphere

1.2: 1.5 h / -72 - -10 °C / Inert atmosphere

1.3: -10 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

3.1: ammonium acetate / ethanol; tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; ammonium acetate; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; hexane;