5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

Base Information

• Chemical Name: 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline
• CAS No.: 957211-46-0
• Molecular Formula: C₁₇H₁₄BrF₄NO
• Molecular Weight: 404.202

Synonyms:5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

Chemical Property of 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

Chemical Property:

Purity/Quality:

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Technology Process of 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

There total 2 articles about 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromo-1-(2-nitro-benzenesulfonyl)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline (957211-45-9) → 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline (957211-46-0)

Guidance literature:

With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

C23H17BrF4N2O5S → 5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline (957211-46-0)

Guidance literature:

With 4-chloro-3-ethylphenol;

DOI:10.1016/j.bmcl.2009.03.051

Reference yield: 96.0%

5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline (957211-46-0) → 5-bromo-2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)quinoline (957212-64-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 2h; Product distribution / selectivity;

upstream raw materials:

5-bromo-1-(2-nitro-benzenesulfonyl)-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

Downstream raw materials:

2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

5-bromo-2-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)quinoline

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