2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Base Information

Chemical Name:2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline
CAS No.:957211-47-1
Molecular Formula:C₂₄H₁₈F₇NO₂
Molecular Weight:485.401
Hs Code.:

Synonyms:2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Suppliers and Price of 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

There total 2 articles about 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 957211-53-9
3-(3-nitro-3'-trifluoromethoxybiphenyl-2-yl)-1-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]propan-1-one

: 957211-47-1
2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 19h; under 2585.81 Torr; Product distribution / selectivity;

Reference yield: 91.0%

: 957211-46-0
5-bromo-2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-1,2,3,4-tetrahydro-quinoline

: 179113-90-7
(3-(trifluoromethoxy)phenyl)boronic acid

: 957211-47-1
2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield: 56.0%

: 359-41-1
1,1,1-trifluoro-2,3-epoxypropane

: 957211-47-1
2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline

: 957211-19-7
1,1,1-trifluoro-3-[2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-propan-2-ol

Guidance literature:: 1,1,1-trifluoro-2,3-epoxypropane; 2-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-5-(3-trifluoromethoxy-phenyl)-1,2,3,4-tetrahydro-quinoline; With ytterbium(III) triflate; In 1,2-dichloro-ethane; at 50 ℃; for 48h; Inert atmosphere;

With water; sodium hydrogencarbonate; In ethyl acetate; 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1021/ol900639j