Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone

Base Information

• Chemical Name: Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone
• CAS No.: 152438-44-3
• Molecular Formula: C₃₃H₄₅N₃O₆
• Molecular Weight: 579.737
• Mol file: 152438-44-3.mol

Synonyms:Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone

Chemical Property of Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone

There total 7 articles about Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.5%

ethyl 4-(aminomethyl)benzoate (366-84-7) + Boc-Tra-Phe-CH2Cl (152438-35-2) → Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone (152438-44-3)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In diethyl ether; water; at 25 ℃; for 168h;

DOI:10.1248/cpb.41.1079

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone (152438-44-3)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N

2: 2.) 7.6 N HCl / 1.) THF, 4 deg C, 5 h, 2.) THF, dioxane, -15 deg C, 3 h

3: 7.0 N HCl / dioxane

4: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

5: 22.5 percent / NaI, NaHCO₃ / diethyl ether; H₂O / 168 h / 25 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

Reference yield:

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5) → Boc-Tra-Phe-4-ethoxycarbonylbenzylaminomethyl ketone (152438-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N

2: 54.7 percent / Et₃N / tetrahydrofuran; dimethylformamide / 4 °C

3: 22.5 percent / NaI, NaHCO₃ / diethyl ether; H₂O / 168 h / 25 °C

With sodium hydrogencarbonate; triethylamine; sodium iodide; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.41.1079

upstream raw materials:

ethyl 4-(aminomethyl)benzoate

Boc-Tra-Phe-CH₂Cl

N-tert-butoxycarbonyl-L-phenylalanine

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid