4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

Base Information

Chemical Name:4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin
CAS No.:1374432-10-6
Molecular Formula:C₂₈H₂₅N₃O₈S
Molecular Weight:563.588
Hs Code.:

Synonyms:4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

Chemical Property:

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Technology Process of 4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

There total 5 articles about 4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388218-57-2
C₂₈H₂₇N₃O₈S₂

: 1374432-10-6
4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; In tetrahydrofuran; at 70 ℃;
DOI:10.1016/j.bmcl.2012.05.059

Reference yield:

: 1374432-04-8
4β-isothiocyanate-4-deoxypodophyllotoxin

: 1374432-10-6
4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: pyridine; p-toluenesulfonyl chloride / tetrahydrofuran / 70 °C

With pyridine; p-toluenesulfonyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2012.05.059

Reference yield:

: 155252-34-9
4β-azido-4-deoxypodophyllotoxin

: 1374432-10-6
4β-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)amino)-4-deoxypodophyllotoxin

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: p-toluenesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

4: tetrahydrofuran / 20 °C

5: pyridine; p-toluenesulfonyl chloride / tetrahydrofuran / 70 °C

With pyridine; palladium 10% on activated carbon; hydrogen; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.05.059