3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

Base Information

• Chemical Name: 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide
• CAS No.: 415974-65-1
• Molecular Formula: C₂₉H₃₅NO₃
• Molecular Weight: 445.602

Synonyms:3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

Chemical Property of 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

Chemical Property:

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Technology Process of 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

There total 3 articles about 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-benzyloxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5(10)-triene-16,17-imide (415974-55-9) → 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5(10)-triene-16,17-imide (415974-65-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/S0968-0896(03)00042-7

Reference yield:

3-benzyloxy-16,17-seco-estra-1,3,5(10)-triene-16,17-dioic acid (415974-44-6) → 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5(10)-triene-16,17-imide (415974-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / urea / 0.75 h / 180 °C

2.1: NaH / dimethylformamide

2.2: 97 percent / dimethylformamide

3.1: 87 percent / H₂ / Pd/C / methanol; tetrahydrofuran

With hydrogen; sodium hydride; urea; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00042-7

Reference yield:

3-benzyloxy-16,17-seco-estra-1,3,5(10)-triene-16,17-imide (415974-45-7) → 3-hydroxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5(10)-triene-16,17-imide (415974-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: 97 percent / dimethylformamide

2.1: 87 percent / H₂ / Pd/C / methanol; tetrahydrofuran

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00042-7

upstream raw materials:

3-benzyloxy-N-(4''-tert-butyl-benzyl)-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

3-benzyloxy-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-dioic acid

3-benzyloxy-16,17-seco-estra-1,3,5⁽¹⁰⁾-triene-16,17-imide

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