(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:165727-50-4
Molecular Formula:C₁₉H₂₇NO₃
Molecular Weight:317.428
Hs Code.:

Synonyms:(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 99113-30-1
((1S,2R)-1-benzyl-2-hydroxybut-3-enyl)carbamic acid tert-butyl ester

: 77-76-9
2,2-dimethoxy-propane

: 165727-50-4
(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 7h; Heating;
DOI:10.1021/jm00038a005

Reference yield:

: 165727-50-4
(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

: (S-(R*,R*))->bis, bis(1,1-dimethylethyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₃OH, -60 deg C, 15 min, 2.) CH₃OH, RT, 15 min

2: 76 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

3: 1.) bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, a) -78 deg C, 90 min, b) RT, 4 h

4: 77 percent / 10percent aq. HCl / 1 h / 50 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; hexamethyldisilazide; ozone; In dichloromethane;
DOI:10.1021/jm00038a005

Reference yield:

: 165727-50-4
(4S,5R)-4-Benzyl-2,2-dimethyl-5-vinyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 165727-53-7
C₃₆H₅₂N₂O₇

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₃OH, -60 deg C, 15 min, 2.) CH₃OH, RT, 15 min

2: 76 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

3: 1.) bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, a) -78 deg C, 90 min, b) RT, 4 h

With pyridine; sodium tetrahydroborate; hexamethyldisilazide; ozone; In dichloromethane;
DOI:10.1021/jm00038a005