tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate
CAS No.:1037743-62-6
Molecular Formula:C₁₆H₂₃BrN₄O₄S
Molecular Weight:447.353
Hs Code.:

Synonyms:tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

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Chemical Property of tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

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Technology Process of tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

There total 1 articles about tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 860354-59-2
3-[(aminocarbonyl)amino]-5-bromo-2-thiophenecarboxylic acid methyl ester

: 625471-18-3
tert-butyl (3S)-3-aminopiperidine-1-carboxylate

: 1037743-62-6
tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

Guidance literature:: With trimethylaluminum; In tetrahydrofuran; at 18 - 25 ℃;

Reference yield: 88.0%

: 1037743-62-6
tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

: 768-35-4
3-fluorophenylboronic acid

: tert-butyl (3S)-3-({[3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-2-thienyl]carbonyl}amino)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dioxane 1,4-; water; at 75 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 1037743-62-6
tert-butyl (3S)-3-[({3-[(aminocarbonyl)amino]-5-bromo-2-thienyl}carbonyl)-amino]piperidine-1-carboxylate

: 121219-16-7
(2,3-difluorophenyl)boronic acid

: C₂₂H₂₆F₂N₄O₄S

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 75 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm300025r