3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

Base Information

Chemical Name:3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile
CAS No.:219762-47-7
Molecular Formula:C₁₅H₁₀BrClN₄
Molecular Weight:361.628
Hs Code.:

Synonyms:3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

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Chemical Property of 3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

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Technology Process of 3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

There total 11 articles about 3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 219762-46-6
4-bromo-2-chloro-1-((methanesulfonyloxy)-methyl)benzene

: 219762-30-8
2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

: 219762-47-7
3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

: 219762-48-8
1-(4-bromo-2-chlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

Guidance literature:: 2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

4-bromo-2-chloro-1-((methanesulfonyloxy)-methyl)benzene; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 219762-47-7
3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

: 219762-48-8
1-(4-bromo-2-chlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide / acetic acid / 13 h / 90 - 100 °C

4.1: DMF (N,N-dimethyl-formamide) / 9 h / 150 °C

4.2: 0.25 h / 70 °C

5.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

5.2: 2 h / 20 °C

With hydrogen bromide; sodium hydride; In DMF (N,N-dimethyl-formamide); acetic acid;

Reference yield:

: 55304-80-8
2,6-dibromo-3-nitropyridine

: 219762-47-7
3-(4-bromo-2-chlorobenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carbonitrile

: 219762-48-8
1-(4-bromo-2-chlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / ethanol / 19 h / 20 °C

2.1: sulfuric acid / acetic acid / 0.67 h / 65 °C

4.1: DMF (N,N-dimethyl-formamide) / 9 h / 150 °C

4.2: 0.25 h / 70 °C

5.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

5.2: 2 h / 20 °C

With sulfuric acid; ammonia; sodium hydride; In DMF (N,N-dimethyl-formamide); ethanol; acetic acid;