(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

Base Information

Chemical Name:(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine
CAS No.:196937-65-2
Molecular Formula:C₁₉H₄₁NO₄Si₂
Molecular Weight:403.71
Hs Code.:

Synonyms:(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

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Chemical Property of (2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

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Technology Process of (2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

There total 1 articles about (2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79200-57-0
(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxylmethyl)-1-aminocyclopentan hydrochloride

: 196937-65-2
(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 5 h / 140 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 3 h

4.1: hydrazine / diethyl ether; ethanol / 20 °C

With 1H-imidazole; sodium hydride; N-ethyl-N,N-diisopropylamine; hydrazine; In diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield: 21.0%

: 196937-71-0
2-Benzoylamino-thiazole-5-carboxylic acid

: 196937-65-2
(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

: 196937-73-2
2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1002/hlca.19970800618

Reference yield:

: 196937-65-2
(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

: 196937-78-7
2-Benzoylamino-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 21 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), (i-Pr)2EtN / dimethylformamide; CH₂Cl₂ / 24 h / Ambient temperature

2: 54 percent / Bu₄NF*3H₂O / tetrahydrofuran / 1.17 h / Ambient temperature

3: Bu₄NClO₄, pyridine / 3 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; tetrabutylammonium perchlorate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618