Technology Process of 2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide
There total 10 articles about 2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
for 24h;
Ambient temperature;
DOI:10.1002/hlca.19970800618
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaOH / H2O / 104.5 h / Ambient temperature; pH=13
2: 66 percent / pyridine / dimethylformamide / 5 h / Ambient temperature
3: 69 percent / Ag2O / 48 h / Heating
4: 56 percent / CF3COOH, phenol / CH2Cl2 / 27 h / Ambient temperature
5: 21 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), (i-Pr)2EtN / dimethylformamide; CH2Cl2 / 24 h / Ambient temperature
With
pyridine; sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; silver(l) oxide; phenol;
In
dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / pyridine / 48 h / Ambient temperature
2: 84 percent / KOH / ethanol; H2O / 5 h / Heating
3: 21 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), (i-Pr)2EtN / dimethylformamide; CH2Cl2 / 24 h / Ambient temperature
With
pyridine; potassium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618
