2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

Base Information

Chemical Name:2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide
CAS No.:196937-73-2
Molecular Formula:C₃₀H₄₇N₃O₆SSi₂
Molecular Weight:633.957
Hs Code.:

2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

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Chemical Property of 2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

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Technology Process of 2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

There total 10 articles about 2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 196937-71-0
2-Benzoylamino-thiazole-5-carboxylic acid

: 196937-65-2
(2R,3S,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-ylamine

: 196937-73-2
2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1002/hlca.19970800618

Reference yield:

: 85026-59-1,305384-32-1,780705-82-0
(-)-(1R,2R,3S,4R)-4-amino-2,3-dihydroxy-1-(hydroxymethyl)cyclopentane

: 196937-73-2
2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / H₂O / 104.5 h / Ambient temperature; pH=13

2: 66 percent / pyridine / dimethylformamide / 5 h / Ambient temperature

3: 69 percent / Ag₂O / 48 h / Heating

4: 56 percent / CF₃COOH, phenol / CH₂Cl₂ / 27 h / Ambient temperature

5: 21 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), (i-Pr)2EtN / dimethylformamide; CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; silver(l) oxide; phenol; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618

Reference yield:

: 98-88-4
benzoyl chloride

: 196937-73-2
2-Benzoylamino-thiazole-5-carboxylic acid ((2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / 48 h / Ambient temperature

2: 84 percent / KOH / ethanol; H₂O / 5 h / Heating

3: 21 percent / 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), (i-Pr)2EtN / dimethylformamide; CH₂Cl₂ / 24 h / Ambient temperature

With pyridine; potassium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618