endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

Base Information

• Chemical Name: endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate
• CAS No.: 145449-95-2
• Molecular Formula: C₂₃H₃₁NO₂
• Molecular Weight: 353.505
• Mol file: 145449-95-2.mol

Synonyms:endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

Chemical Property of endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate

There total 1 articles about endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

endo-8-(1-methylethyl)-8-azabicyclo<3.2.1>octan-3-ol (3423-25-4) + 2-phenyl-2-cyclohexene-1-carbonyl chloride (145450-39-1) → endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate (145449-95-2)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; for 9h; Heating;

DOI:10.1016/0223-5234(92)90179-5

Reference yield: 89.0%

endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate (145449-95-2) + methyl iodide (74-88-4) → endo-syn-8-methyl-8-(1-methylethyl)-3-<<2-phenyl-2-cyclohexene-1-yl)-carbonyl>oxy>-8-azoniabicyclo<3.2.1>octane iodide (145449-99-6)

Guidance literature:

In acetonitrile; at 50 ℃; for 3h;

DOI:10.1016/0223-5234(92)90179-5

Reference yield: 84.0%

endo-8-(1-methylethy)-8-azabicyclo<3.2.1>oct-3-yl 2-phenyl-2-cyclohexene-1-carboxylate (145449-95-2) → (1R,2S)-2-Phenyl-cyclohexanecarboxylic acid (1R,3R,5S)-8-isopropyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (145450-34-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1016/0223-5234(92)90179-5

upstream raw materials:

endo-8-(1-methylethyl)-8-azabicyclo<3.2.1>octan-3-ol

2-phenyl-2-cyclohexene-1-carbonyl chloride

Downstream raw materials:

(1R,3R,5S,8R)-8-Isopropyl-8-methyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

(1R,3R,5S,8R)-8-Ethyl-8-isopropyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide

(1R,3R,5S,8R)-8-Butyl-8-isopropyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; iodide

(1R,3R,5S,8R)-8-Ethyl-8-isopropyl-3-(2-phenyl-cyclohex-2-enecarbonyloxy)-8-azonia-bicyclo[3.2.1]octane; iodide