4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone

Base Information

• Chemical Name: 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone
• CAS No.: 35867-79-9
• Molecular Formula: C₃₂H₂₅N₅O₈
• Molecular Weight: 607.579
• Mol file: 35867-79-9.mol

Synonyms:4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone

Chemical Property of 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone

There total 5 articles about 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 4-(Trimethylsilylamino)-7-(trimethylsilyloxy)pteridin (1070990-50-9) → 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone (35867-79-9)

Guidance literature:

With boron trifluoride diethyl etherate; In ethanol; chloroform; for 3h; Ambient temperature;

Reference yield: 22.0%

2,3,5-tri-O-benzoyl-1-bromo-α-D-erythro-pentofuranose (16205-59-7) + 4-amino-7(8H)-pteridone (22005-66-9) → 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone (35867-79-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1016/0040-4039(96)01929-6

Reference yield:

4-amino-7(8H)-pteridone (22005-66-9) → 4-amino-8-(2,3,5-tri-O-benzoyl-β-D-erythro-pentofuranosyl)-7(8H)-pteridone (35867-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonum sulfate / 3 h / Heating

2: 53 percent / borotrifluorid etherate / ethanol; CHCl₃ / 3 h / Ambient temperature

With ammonium sulfate; boron trifluoride diethyl etherate; In ethanol; chloroform;

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

4-(Trimethylsilylamino)-7-(trimethylsilyloxy)pteridin

2,3,5-tri-O-benzoyl-1-bromo-α-D-erythro-pentofuranose

4-amino-7(8H)-pteridone

Downstream raw materials:

4-amino-2-phenyl-8-β-D-erythro-pentofuranosyl-7(8H)-pteridone