[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester
CAS No.:1262860-10-5
Molecular Formula:C₁₃H₁₃F₄NO₂
Molecular Weight:291.245
Hs Code.:

Synonyms:[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

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Chemical Property of [2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

There total 1 articles about [2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68014-21-1
triphenyl(t-butoxycarbonylimino)phosphorane

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 1262860-10-5
[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

Guidance literature:: In toluene; at 120 ℃; for 18h;

Reference yield:

: 1262860-10-5
[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

: 2622-05-1
allylmagnesium bromide

: 1262860-11-6
[1-(2-fluoro-phenyl)-1-trifluoromethyl-but-3-enyl]-carbamic acid tert-butyl ester

Guidance literature:: [2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester; allylmagnesium bromide; In tetrahydrofuran; at -75 - -60 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1262860-10-5
[2,2,2-Trifluoro-1-(2-fluoro-phenyl)-eth-(Z)-ylidene]-carbamic acid tert-butyl ester

: 1262856-23-4
5-Cyano-pyridine-2-carboxylic acid [3-(3-amino-5-trifluoromethyl-2,5,6,7-tetrahydro-[1,4]oxazepin-5-yl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: tetrahydrofuran

2: hydrogenchloride; sodium hydrogencarbonate; sodium tetrahydroborate; O₃ / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; oxygen

3: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

4: potassium tert-butylate / ethyl acetate; tert-butyl alcohol; tetrahydrofuran

5: tetrahydrofuran

6: potassium carbonate / ammonia; methanol

7: potassium nitrate / sulfuric acid

8: DIPEA / dichloromethane; tetrahydrofuran

9: Pd on charcoal / ethanol; tetrahydrofuran

10: 1,2-dichloro-ethane; DIPEA / N,N-dimethyl-formamide

11: hydrogenchloride; trifluoroacetic acid / dichloromethane; ethyl acetate; diethyl ether; tetrahydrofuran

With pyridine; hydrogenchloride; sodium tetrahydroborate; O₃; DIPEA; potassium tert-butylate; sodium hydrogencarbonate; potassium carbonate; potassium nitrate; 1,2-dichloro-ethane; trifluoroacetic acid; Pd on charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; diethyl ether; ethanol; dichloromethane; sulfuric acid; ammonia; oxygen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;