2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

Base Information

Chemical Name:2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide
CAS No.:1262860-13-8
Molecular Formula:C₁₂H₁₂ClF₄NO₂
Molecular Weight:313.679
Hs Code.:

Synonyms:2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

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Chemical Property of 2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

Chemical Property:

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Technology Process of 2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

There total 5 articles about 2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262860-12-7
[1-(2-Fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-carbamic acid tert-butyl ester

: 79-04-9
chloroacetyl chloride

: 1262860-13-8
2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

Guidance literature:: [1-(2-Fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; for 1h;

chloroacetyl chloride; With potassium carbonate; In pyridine; methanol; at -15 - -5 ℃; for 0.75h;

In dichloromethane;

Reference yield:

: 1262860-14-9
C₁₄H₁₃Cl₂F₄NO₃

: 1262860-13-8
2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

Guidance literature:: With potassium carbonate; In methanol; for 0.75h;

Reference yield:

: 124004-75-7
α,α,α-trifluoro-2-fluoroacetophenone

: 1262860-13-8
2-chloro-N-[1-(2-fluoro-phenyl)-3-hydroxy-1-trifluoromethyl-propyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene; hexane

2: tetrahydrofuran

3: hydrogenchloride; sodium hydrogencarbonate; sodium tetrahydroborate; O₃ / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; oxygen

4: potassium carbonate; pyridine; DIPEA / hydrogenchloride; dichloromethane; 1,4-dioxane; methanol

With pyridine; hydrogenchloride; sodium tetrahydroborate; O₃; DIPEA; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; methanol; hexane; dichloromethane; oxygen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; toluene;