C₂₀H₁₉ClN₂O₄

Base Information

• Chemical Name: C₂₀H₁₉ClN₂O₄
• CAS No.: 1383785-75-8
• Molecular Formula: C₂₀H₁₉ClN₂O₄
• Molecular Weight: 386.835
• Mol file: 1383785-75-8.mol

Synonyms:C₂₀H₁₉ClN₂O₄

Chemical Property of C₂₀H₁₉ClN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉ClN₂O₄

There total 5 articles about C₂₀H₁₉ClN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-(benzyloxy)-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate (1174226-00-6) + 3-chloropropylamine hydrochloride (6276-54-6) → C20H19ClN2O4 (1383785-75-8)

Guidance literature:

In toluene; for 12h; Reflux;

Reference yield:

dimethyl homophthalate (716-43-8) → C20H19ClN2O4 (1383785-75-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 - -5 °C / Inert atmosphere

1.2: 0.33 h

2.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.5 h / -25 °C

2.2: 12 h / 20 °C

3.1: potassium hydroxide / methanol / 0.08 h

4.1: toluene / 12 h / Reflux

With 4-methyl-morpholine; n-butyllithium; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

Homophthalic acid (89-51-0) → C20H19ClN2O4 (1383785-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / Reflux

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 - -5 °C / Inert atmosphere

2.2: 0.33 h

3.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.5 h / -25 °C

3.2: 12 h / 20 °C

4.1: potassium hydroxide / methanol / 0.08 h

5.1: toluene / 12 h / Reflux

With 4-methyl-morpholine; n-butyllithium; thionyl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

upstream raw materials:

dimethyl homophthalate

Homophthalic acid

methyl 2-(benzyloxy)-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate

3-chloropropylamine hydrochloride