3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

Base Information

Chemical Name:3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester
CAS No.:1455092-38-2
Molecular Formula:C₂₄H₂₂ClN₃O₅
Molecular Weight:467.909
Hs Code.:

Synonyms:3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

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Chemical Property of 3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

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Technology Process of 3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

There total 3 articles about 3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59193-77-0
3-amino-2,2-dimethylpropionic acid ethyl ester

: 1455092-37-1
7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxylic acid methyl ester

: 1455092-38-2
3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: In ethanol; at 150 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 1572-98-1
2-cyano-2-methyl-propionic acid ethyl ester

: 1455092-38-2
3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: ethanol / 1.5 h / 150 °C / Microwave irradiation

With hydrogen; In ethanol;

Reference yield:

: 7-(3-chlorophenoxy)-4-hydroxy-1-iodoisoquinoline-3-carboxylic acid methyl ester

: 1455092-38-2
3-{[7-(3-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.12 h / 120 °C

2: ethanol / 1.5 h / 150 °C / Microwave irradiation

In ethanol; N,N-dimethyl-formamide;