(E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate

Base Information

Chemical Name:(E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate
CAS No.:1223593-73-4
Molecular Formula:C₁₅H₁₉N₃O₅
Molecular Weight:321.333
Hs Code.:
Mol file:1223593-73-4.mol

Synonyms:(E)-tert-butyl 2-(4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzoyl)hydrazinecarboxylate

Suppliers and Price of (E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate

Chemical Property:

PKA:8.63±0.23(Predicted)
Density:1.272±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate

There total 4 articles about (E)-tert-butyl 2-(4-(3-(hydroxyaMino)-3-oxoprop-1-en-1-yl)benzoyl)hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.8%

: 1223593-71-2
(E)-tert-butyl 2-(4-(3-ethoxy-3-oxoprop-1-enyl)benzoyl)hydrazinecarboxylate

: 1223593-73-4
(E)-tert-butyl 2-(4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzoyl)hydrazinecarboxylate

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In methanol; ethanol; for 18h;

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 1223593-73-4
(E)-tert-butyl 2-(4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzoyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / pyridine / 18 h / 100 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine; methyl chloroformate / dichloromethane / 1 h / 0 °C

3.1: dmap / dichloromethane / 3 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; methanol / 18 h

With piperidine; hydroxylamine hydrochloride; triethylamine; methyl chloroformate; sodium hydroxide; dmap; In pyridine; methanol; ethanol; dichloromethane;

Reference yield:

: 1223593-69-8
(E)-ethyl 3-(4-(hydrazinecarbonyl)phenyl)acrylate

: 1223593-73-4
(E)-tert-butyl 2-(4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzoyl)hydrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: hydroxylamine hydrochloride; sodium hydroxide / ethanol; methanol / 18 h

With hydroxylamine hydrochloride; sodium hydroxide; dmap; In methanol; ethanol; dichloromethane;