acide 2-methylamino-3-methyl-3-hydroxy butanoique

Base Information

• Chemical Name: acide 2-methylamino-3-methyl-3-hydroxy butanoique
• CAS No.: 108677-84-5
• Molecular Formula: C₆H₁₃NO₃
• Molecular Weight: 147.174
• Hs Code.: 2922500090
• Mol file: 108677-84-5.mol

Synonyms:acide 2-methylamino-3-methyl-3-hydroxy butanoique

Chemical Property of acide 2-methylamino-3-methyl-3-hydroxy butanoique

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-3-methyl-2-(methylamino)butyricAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acide 2-methylamino-3-methyl-3-hydroxy butanoique

There total 6 articles about acide 2-methylamino-3-methyl-3-hydroxy butanoique which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((N-methyl-N-trimethylsilyl)amino)ketene bis(trimethylsilyl)acetal (108671-39-2) + acetone (67-64-1) → acide 2-methylamino-3-methyl-3-hydroxy butanoique (108677-84-5)

Guidance literature:

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; Yield given. Multistep reaction; 1) CH₂Cl₂, 0 deg C, 12 h;

DOI:10.1016/S0040-4039(00)83885-X

Reference yield:

β-methoxy-α-methylamino-isovaleric acid → acide 2-methylamino-3-methyl-3-hydroxy butanoique (108677-84-5)

Guidance literature:

With hydrogen bromide;

Reference yield:

β-methoxy-α-[methyl-(toluene-4-sulfonyl)-amino]-isovaleric acid → acide 2-methylamino-3-methyl-3-hydroxy butanoique (108677-84-5)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

3,3-dimethyl-oxirane-2-carboxylic acid

methylamine

((N-methyl-N-trimethylsilyl)amino)ketene bis(trimethylsilyl)acetal

acetone

Downstream raw materials:

Boc-L-Leu-L-HOMeVal-D-Hmp-OPac

Boc-L-Leu-DL-HOMeVal-D-Hmp-OPac

C₆₁H₈₆N₆O₁₃