2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

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Chemical Name:2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid
CAS No.:1459258-07-1
Molecular Formula:C₂₃H₂₃N₅O₃
Molecular Weight:417.467
Hs Code.:

Synonyms:2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

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Chemical Property of 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

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Technology Process of 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

There total 6 articles about 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1459258-06-0
methyl 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinate

: 1459258-07-1
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

Reference yield:

: 1186647-69-7
4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine

: 1459258-07-1
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

3: trans-bis(triphenylphosphine)palladium dichloride / toluene / 12 h / 110 °C / Inert atmosphere

4: lithium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; water; N-ethyl-N,N-diisopropylamine; lithium chloride; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; butan-1-ol;

Reference yield:

: 1246349-97-2
4-chloro-3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridine

: 1459258-07-1
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

2: trans-bis(triphenylphosphine)palladium dichloride / toluene / 12 h / 110 °C / Inert atmosphere

3: lithium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

4: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; water; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol; toluene; butan-1-ol;