2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

Base Information

Chemical Name:2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide
CAS No.:1459258-08-2
Molecular Formula:C₂₅H₂₈N₆O₂
Molecular Weight:444.536
Hs Code.:

Synonyms:2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

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Chemical Property of 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

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Technology Process of 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

There total 7 articles about 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1459258-07-1
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinic acid

: 506-59-2
N,N-dimethylammonium chloride

: 1459258-08-2
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1459258-06-0
methyl 2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinate

: 1459258-08-2
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

2: HATU; triethylamine / N,N-dimethyl-formamide / 20 °C

With water; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1186647-69-7
4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine

: 1459258-08-2
2-(4-(isopropylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 2 h / 170 °C / Microwave irradiation

3: trans-bis(triphenylphosphine)palladium dichloride / toluene / 12 h / 110 °C / Inert atmosphere

4: lithium chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

6: HATU; triethylamine / N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium chloride; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; butan-1-ol;