N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Base Information

• Chemical Name: N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester
• CAS No.: 263276-03-5
• Molecular Formula: C₂₂H₂₅Cl₂N₃O₅
• Molecular Weight: 482.364
• Mol file: 263276-03-5.mol

Synonyms:N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Chemical Property of N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester

There total 6 articles about N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester (67630-01-7) + 3,5-dichloroisonicotinoyl chloride (229328-97-6) → N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester (263276-03-5)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane;

DOI:10.1016/S0960-894X(02)00237-8 DOI:10.1016/S0960-894X(02)00075-6

Reference yield:

(S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester (67630-01-7) → N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester (263276-03-5)

Guidance literature:

3,5-dichloropyridine-4-carboxylic acid; In DMF (N,N-dimethyl-formamide); dichloromethane; for 5h; Heating / reflux;

(S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester; With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 1.08333h;

Reference yield:

3,5-dichloropyridine-4-carboxylic acid (13958-93-5) → N-Boc-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester (263276-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂

2: N-methyl morpholine / CH₂Cl₂

With 4-methyl-morpholine; thionyl chloride; In dichloromethane;

DOI:10.1016/S0960-894X(02)00237-8 DOI:10.1016/S0960-894X(02)00075-6

upstream raw materials:

(S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester

3,5-dichloroisonicotinoyl chloride

3,5-dichloropyridine-4-carboxylic acid

3,5-dichloropyridine

Downstream raw materials:

N-[N-Boc-4(R)-cyclobutylamino-(L)-prolyl]-4-[(3',5'-dichloroisonicotinoyl)amino]-(L)-phenylalanine ethyl ester

(S,R,S,S)-N-(N-Boc-octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

N-[N-(tert-butoxycarbonyl)-4(R)-3,3-dimethylpiperidino-(L)-prolyl]-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester

(S,R,S,S)-N-(octahydroisoindol-1-carboxyl)-4-[(3',5'-dichloro-isonicotinoyl)amino]-(L)-phenylalanine ethyl ester hydrochloride