3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

Base Information

Chemical Name:3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine
CAS No.:957756-71-7
Molecular Formula:C₁₈H₁₅ClN₄OS
Molecular Weight:370.862
Hs Code.:

Synonyms:3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

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Chemical Property of 3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

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Technology Process of 3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

There total 2 articles about 3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1083196-18-2
4-amino-5-[2-(4-hydroxyphenyl)ethyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione

: 536-38-9
4-chlorobenzoylmethyl bromide

: 957756-71-7
3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

Guidance literature:: In ethanol; for 1h; Reflux;
DOI:10.1016/j.ejmech.2011.09.020

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 957756-71-7
3-[2-(4-hydroxyphenyl)ethyl]-6-(4-chlorophenyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / 160 - 170 °C / Neat (no solvent)

2: ethanol / 1 h / Reflux

In ethanol;
DOI:10.1016/j.ejmech.2011.09.020