2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

Base Information

Chemical Name:2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol
CAS No.:1427407-29-1
Molecular Formula:C₂₀H₁₆F₃NO₂
Molecular Weight:359.348
Hs Code.:

Synonyms:2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

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Chemical Property of 2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

Chemical Property:

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Technology Process of 2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

There total 7 articles about 2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1427407-28-0
N-(2,6-difluoro-3-hydroxy-phenyl)-3-(3-fluorophenyl)-5-methoxy-benzamide

: 1427407-29-1
2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 1427407-27-9
methyl 3-(3-fluorophenyl)-5-methoxy-benzoate

: 1427407-29-1
2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3: tetrahydrofuran / 2 h / 0 - 20 °C

4: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

With borane-THF; oxalyl dichloride; water; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 140472-69-1
3-bromo-5-hydroxy-benzoic acid

: 1427407-29-1
2,4-difluoro-3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; methanol / 4 h / 70 °C / Inert atmosphere

3.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

5.1: tetrahydrofuran / 2 h / 0 - 20 °C

6.1: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; oxalyl dichloride; water; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;