N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine
CAS No.:1365802-37-4
Molecular Formula:C₂₅H₁₈F₆N₆
Molecular Weight:516.449
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

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Chemical Property of N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

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Technology Process of N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

There total 6 articles about N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1365803-34-4
6-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-1H-indazole-3-carbaldehyde

: 74-89-5
methylamine

: 1365802-37-4
N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

Guidance literature:: With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; at 45 ℃; for 48h; sealed tube;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1365802-37-4
N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3: sodium cyanoborohydride / acetic acid / tetrahydrofuran; methanol / 48 h / 45 °C / sealed tube

With potassium phosphate; sodium hydride; sodium cyanoborohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; mineral oil;

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 1365802-37-4
N-[3,5-bis(trifluoromethyl)phenyl]-4-{3-[(methylamino)methyl]-1H-indazol-6-yl}phthalazin-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3: sodium cyanoborohydride / acetic acid / tetrahydrofuran; methanol / 48 h / 45 °C / sealed tube

With potassium phosphate; sodium hydride; sodium cyanoborohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; mineral oil;