1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine

Base Information

• Chemical Name: 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine
• CAS No.: 75590-41-9
• Molecular Formula: C₂₃H₂₅ClN₂O₅
• Molecular Weight: 444.915
• Mol file: 75590-41-9.mol

Synonyms:1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine

Chemical Property of 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine

There total 5 articles about 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>-2-hydroxypropyl>-4-(4-chlorobenzyl)piperazine (75590-40-8) → 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine (75590-41-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; under 760 Torr;

DOI:10.1021/jm00377a013

Reference yield:

1-[(4-chlorophenyl)methyl]piperazine (23145-88-2) → 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine (75590-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / ethanol / 1.5 h / Heating

2: 100 percent / H₂ / 10percent Pd/C / dimethylformamide / 760 Torr

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00377a013

Reference yield:

ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate (55037-87-1) → 1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxycoumarin-7-yloxy)propyl]piperazine (75590-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 20percent w/v aq. NaOH / 2-ethoxy-ethanol / 18 h / Heating

2: 62 percent / ethanol / 1.5 h / Heating

3: 100 percent / H₂ / 10percent Pd/C / dimethylformamide / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In 2-ethoxy-ethanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00377a013

upstream raw materials:

1-<3-<<4-(benzyloxy)coumarin-7-yl>oxy>-2-hydroxypropyl>-4-(4-chlorobenzyl)piperazine

1-[(4-chlorophenyl)methyl]piperazine

ethyl 4-(4-chlorobenzyl)piperazine-1-carboxylate

4-(benzyloxy)-7-hydroxycoumarin

Downstream raw materials:

1-(4-chlorobenzyl)-4-[2-hydroxy-3-(4-hydroxy-3-nitrocoumarin-7-yloxy)propyl]piperazine