2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Base Information

Chemical Name:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)
CAS No.:1443053-37-9
Molecular Formula:C₂₅H₃₂N₂O₈
Molecular Weight:488.538
Hs Code.:

Synonyms:2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

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Chemical Property of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

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Technology Process of 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

There total 12 articles about 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443052-79-6
ethyl 5-(dimethylcarbamoyl)-3,4-dihydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 79-30-1
isobutyryl chloride

: 1443053-37-9
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: With sodium acetate; at 100 ℃; for 2h;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1443053-37-9
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1: sodium acetate; sodium iodide / water / 3 h / 90 °C

2: water; sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 40 °C

3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 60 °C

5: sodium ethanolate / ethanol / 1.5 h / 85 °C

6: sodium acetate / 2 h / 100 °C

With water; sodium ethanolate; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;

Reference yield:

: 98269-30-8
diethyl 2,2’-((4-methoxyphenyl)azanediyl)diacetate

: 1443053-37-9
2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(2-methylpropanoate)

Guidance literature:: Multi-step reaction with 6 steps

1: sodium ethanolate / ethanol / 1 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3: water; sodium hydroxide / tetrahydrofuran; ethanol / 16 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: hydrogen; palladium 10% on activated carbon / ethanol / 1.5 h / 20 °C

6: sodium acetate / 2 h / 100 °C

With palladium 10% on activated carbon; water; hydrogen; sodium ethanolate; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;