6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone

Base Information

• Chemical Name: 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone
• CAS No.: 104960-61-4
• Molecular Formula: C₁₇H₉F₃N₂O₂S
• Molecular Weight: 362.332
• Mol file: 104960-61-4.mol

Synonyms:6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone

Chemical Property of 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone

There total 5 articles about 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

acetic anhydride (108-24-7) + 3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine (104960-56-7) → 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone (104960-61-4)

Guidance literature:

for 1h; Heating;

Reference yield:

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) → 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone (104960-61-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / triethylamine / ethanol / 24 h / 20 °C

2: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C

3: 59 percent / sodium ethanolate / ethanol / 2 h / Heating

4: 71 percent / 1 h / Heating

With potassium hydroxide; sodium ethanolate; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (104960-49-8) → 6-methyl-4-trifluoromethyl-2-phenylpyrido<2',3':5,4>thieno<3,2-d><1,3>-8-oxazinone (104960-61-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C

2: 59 percent / sodium ethanolate / ethanol / 2 h / Heating

3: 71 percent / 1 h / Heating

With potassium hydroxide; sodium ethanolate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

acetic anhydride

3-amino-2-carboxy-4-trifluoromethyl-6-phenylthieno<2,3-b>pyridine

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Downstream raw materials:

2-methyl-9-trifluoromethyl-7-phenylpyrido[2',3':5,4]thieno[3,2-d]-4(3H)-pyrimidone