2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Base Information

• Chemical Name: 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
• CAS No.: 1402002-80-5
• Molecular Formula: C₂₄H₂₂F₄N₄O₄
• Molecular Weight: 506.457
• Mol file: 1402002-80-5.mol

Synonyms:2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Chemical Property of 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

There total 2 articles about 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.4%

2-(2-(4-fluoro-2-(2,2,2-trifluoroacetyl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione + trimethylsulfoxonium iodide (1774-47-6) → 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione (1402002-80-5)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.25h; Inert atmosphere;

2-(2-(4-fluoro-2-(2,2,2-trifluoroacetyl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione; In dimethyl sulfoxide; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/cmdc.201700333

Reference yield:

5-fluoro-2-hydroxybenzaldehyde (347-54-6) → 2-(2-(4-fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenoxy)ethyl)-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione (1402002-80-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 1.5 h / Heating

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

4.1: potassium tert-butylate / dimethyl sulfoxide / 0.25 h / 20 °C / Inert atmosphere

4.2: 15 h / 20 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201700333

upstream raw materials:

5-fluoro-2-hydroxybenzaldehyde

trimethylsulfoxonium iodide