Technology Process of 5-(2,6-difluorophenyl)-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carbothioamide
There total 10 articles about 5-(2,6-difluorophenyl)-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carbothioamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; diammonium sulfide;
at 100 ℃;
for 0.333333h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C
2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere
3.1: 0.17 h / Inert atmosphere
3.2: 1.5 h / 130 °C
4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C
5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
7.1: 1,4-dioxane / 0.17 h / Inert atmosphere
7.2: 4 h / Reflux
8.1: hydrogenchloride / 0.08 h / 100 °C / Microwave irradiation
8.2: pH 7
9.1: diammonium sulfide; methanol / 0.33 h / 100 °C / Microwave irradiation
With
hydrogenchloride; methanol; diammonium sulfide; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C
2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere
3.1: 0.17 h / Inert atmosphere
3.2: 1.5 h / 130 °C
4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C
5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
7.1: 1,4-dioxane / 0.17 h / Inert atmosphere
7.2: 4 h / Reflux
8.1: hydrogenchloride / 0.08 h / 100 °C / Microwave irradiation
8.2: pH 7
9.1: diammonium sulfide; methanol / 0.33 h / 100 °C / Microwave irradiation
With
hydrogenchloride; methanol; diammonium sulfide; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
![5-(2,6-difluorophenyl)-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile](/Databaselist/images/loading.webp)
