dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

Base Information

Chemical Name:dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate
CAS No.:669088-35-1
Molecular Formula:C₅₄H₉₅N₄O₁₁PSi₄
Molecular Weight:1119.68
Hs Code.:

Synonyms:dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

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Chemical Property of dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

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Technology Process of dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

There total 8 articles about dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 50651-75-7
silver dibenzylphosphate

: 669088-31-7
4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]-1-iodobutane

: 669088-35-1
dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

Guidance literature:: In acetonitrile; for 8h; Heating;
DOI:10.1021/jo030278k

Reference yield:

: 6320-15-6
6-chloro-2,4-dimethoxypyrimidine

: 669088-35-1
dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 64 percent / H₂SO₄; HNO₃ / 2.5 h / 80 - 85 °C

2: 75 percent / dimethylformamide / 48 h / 23 °C

3: 75 percent / imidazole / dimethylformamide / 48 h / 23 °C

4: H₂ / Pd/C / methanol / 72 h / 23 °C / 72.4 Torr

5: Et₃N / CH₂Cl₂ / 6 h / 0 - 20 °C

6: NaOEt / ethanol / 24 h / Heating

7: 80 percent / K₂CO₃ / dimethylformamide / 24 h / 23 °C

8: 83 percent / acetonitrile / 8 h / Heating

With 1H-imidazole; sulfuric acid; hydrogen; nitric acid; sodium ethanolate; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo030278k

Reference yield:

: 60331-03-5
4-chloro-2,6-dimethoxy-5-nitropyrimidine

: 669088-35-1
dibenzyl 4-[9-(2',3',4',5'-tetra-O-tert-butyl(dimethyl)silyl-D-ribityl)-2,6-dimethoxy-8-oxo-7H,9H-purin-7-yl]butane-1-phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / dimethylformamide / 48 h / 23 °C

2: 75 percent / imidazole / dimethylformamide / 48 h / 23 °C

3: H₂ / Pd/C / methanol / 72 h / 23 °C / 72.4 Torr

4: Et₃N / CH₂Cl₂ / 6 h / 0 - 20 °C

5: NaOEt / ethanol / 24 h / Heating

6: 80 percent / K₂CO₃ / dimethylformamide / 24 h / 23 °C

7: 83 percent / acetonitrile / 8 h / Heating

With 1H-imidazole; hydrogen; sodium ethanolate; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo030278k