6320-15-6

Basic information

• Product Name: 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE
• Synonyms: AURORA KA-4916;2,4-DIMETHOXY-6-CHLOROPYRIMIDINE;6-CHLORO-2,4-DIMETHOXYPYRIMIDINE;4-CHLORO-2,6-DIMETHOXYPYRIMIDINE;6-chloro-2,4-dimethixypyrimidine;6-CHLORO-2,4-DIMETHOXYPYRIMIDINE, 98+%;2,6-Dimethoxy-4-chloropyrimidine;4-diMethoxy pyriMidine
• CAS NO: 6320-15-6
• Molecular Formula: C₆H₇ClN₂O₂
• Molecular Weight: 174.58
• EINECS: 228-669-6
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Aromatics;Heterocycles
• Mol File: 6320-15-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-76 °C(lit.)
• Boiling Point: 280.6 °C at 760 mmHg
• Flash Point: 123.5 °C
• Appearance: white powder or flakes.
• Density: 1.285 g/cm³
• Vapor Pressure: 0.00637mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: -20°C
• Solubility: Soluble in chloroform, ethyl acetate and methanol.
• PKA: -1.92±0.30(Predicted)
• Sensitive: Hygroscopic
• BRN: 137581
• CAS DataBase Reference: 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE(6320-15-6)
• EPA Substance Registry System: 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE(6320-15-6)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 6320-15-6(Hazardous Substances Data)

Usage

Uses

It is used in the synthesis of silyl and stannyl pyrimidines.

InChI:InChI=1/C6H7ClN2O2/c1-10-5-3-4(7)8-6(9-5)11-2/h3H,1-2H3

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 124-41-4 sodium methylate 
• 43212-41-5 2,4-dichloro-6-methoxypyrimidine 
• 71885-70-6 2,6-dimethoxy-pyrimidine-4-sulfonic acid 
• 1074-40-4 4,6-dichloro-2-methoxypyrimidine 

Downstream Products

• 77767-96-5 Trimethyl-4-(2,6-dimethoxypyrimidinyl)ammoniumchlorid 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 4270-27-3 6-chlorouracil 
• 3289-50-7 2,6-dimethoxypyrimidin-4-amine 
• 42362-16-3 5-bromo-4-chloro-2,6-dimethoxypyrimidine 
• 89943-44-2 2,4-dimethoxy-6-methylsulfanyl-pyrimidine 
• 409112-12-5 2,6-dimethoxy-pyrimidine-4-sulfenic acid amide 
• 317828-06-1 2-[(S)-1-Phenylethylamino]-4-[5-(2,6-dimethoxypyrimidin-4-yl)benzimidazol-1-yl]pyrimidine 
• 1236194-04-9 diphenyl(2,4-dimethoxy-6-pyrimidyl)arsane 
• 1236194-07-2 diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane 

Relevant articles and documents

HIV reverse transcriptase/integrase double target inhibitors 6-benzoyl-substituted uracils preparation and application

The invention relates to application of a novel HIV retrovirus/intergrase double-target inhibitor 6-benzoyl substituted uracil compounds and pharmaceutical compositions containing the compounds to AIDS-treating medicines and antiviral medicines. The invention also relates to a preparation method of the compounds. The compounds are shown as a general formula I, and all groups in the general formula I are defined in right claim, R1=H, CH2OH, CHO, COOH, COOCH3, COOCH2CH3, CONHCH3, CONHCH2CH3, and R=CH3, H, F.

PYRIMIDINE SUBSTITUTED MACROCYCLIC HCV INHIBITORS

Compounds of the Formula (I) including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising these compounds as active ingredient.

Reactions of 4a-Peroxides and 4a-Pseudobases of N10- and N5-Phenethylflavins

A number of N5,N10-dialkylisoalloxazines have been synthesized in which either the N5 or the N10 substituent is a meta-substituted phenethyl group.Some of these compounds have been subjected to experiments in order to determine whether an intramolecular transfer of oxygen can occur between the flavin and the phenethyl group (a model of monooxygenase).When in the 1,5-dihydro reduced state, N5-alkyl-substituted isoalloxazines react with molecular oxygen to dive 4a-hydroperoxy derivatives.The hydroperoxides of the N5-ethyl-N10-phenethylflavins provide 4a-pseudobases on spontaneous decomposition.These in turn undergo ring contraction in base to yield 10a-spirohydantoins (Scheme V).The structure of 10a-spirohydantoin (28b) is as established by X-ray crystallographic technique.Spontaneous decomposition of 4a-hydroperoxides is not accompanied by intramolecular oxygen transfer to the phenethyl substituent groups at N10 or N5 (eq.4) 10a-Spirohydantoins may also be obtained by base treatment of 4a-pseudobases that have been prepared separately from the oxidized isoalloxazine (i.e., flavinium cation). 4a-(Allylperoxy)flavin derivatives, obtained by addition of alkyl peroxides to flavinium cations, undergo both spontaneous and photochemocal conversion to 10a-spirohydantoin.These findings are discissed in therms of proposals which have been made for the mechanism of action of flavoenzyme monooxygenases.