2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

Base Information

Chemical Name:2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester
CAS No.:168965-82-0
Molecular Formula:C₂₆H₃₈N₂O₇
Molecular Weight:490.597
Hs Code.:

Synonyms:2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

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Chemical Property of 2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

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Technology Process of 2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

There total 4 articles about 2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 168965-81-9
Toluene-4-sulfonic acid 5-((Z)-dec-1-enyl)-2-nitro-benzyl ester

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 168965-82-0
2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jm970704s

Reference yield:

: 64152-09-6
3-Methoxycarbonyl-4-nitrobenzoic acid

: 168965-82-0
2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / BH₃*methyl sulfide / tetrahydrofuran / 5 h / Heating

2: 94 percent / PCC, neutral activity I Al₂O₃ / CH₂Cl₂ / 18 h / 0 °C

3: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 40 min, 2.) THF, hexane, 0 deg C, 3.5 h

4: 82 percent / LiBH₄ / tetrahydrofuran / 17 h / 0 - 20 °C

5: NaH / toluene / 2 h / Ambient temperature

6: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

With aluminum oxide; lithium borohydride; n-butyllithium; dimethylsulfide borane complex; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm970704s

Reference yield:

: 168965-80-8
[5-((Z)-Dec-1-enyl)-2-nitro-phenyl]-methanol

: 168965-82-0
2-Acetylamino-2-[5-((Z)-dec-1-enyl)-2-nitro-benzyl]-malonic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / toluene / 2 h / Ambient temperature

2: 77 percent / NaH / dimethylformamide / 16 h / Ambient temperature

With sodium hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm970704s