4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

Base Information

Chemical Name:4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile
CAS No.:1181566-90-4
Molecular Formula:C₂₂H₁₄BrFN₂O
Molecular Weight:421.268
Hs Code.:

Synonyms:4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

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Chemical Property of 4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

Chemical Property:

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Technology Process of 4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

There total 1 articles about 4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374633-29-1
4-bromo-1H-indole-6-carbonitrile

: 133057-83-7
4-benzyloxy-3-fluorophenylboronic acid

: 1181566-90-4
4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

Guidance literature:: With oxygen; triethylamine; copper diacetate; In dichloromethane; at 20 ℃; for 32h; Molecular sieve;

Reference yield:

: 1181566-90-4
4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

: 1181566-91-5
1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indole-6-carbonitrile

Guidance literature:: 4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile; With water; potassium hydroxide; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 85 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; pH=7;

Reference yield:

: 1181566-90-4
4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile

: 1181566-61-9
1-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-1H-indole-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 85 °C

1.2: pH 7

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate

With water; hydrogen; potassium hydroxide; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; ethyl acetate;