Technology Process of 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indole-6-carbonitrile
There total 3 articles about 1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-hydroxy-1H-indole-6-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile;
With
water; potassium hydroxide; tert-butyl XPhos;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane;
at 85 ℃;
for 1h;
With
hydrogenchloride;
In
1,4-dioxane; water; ethyl acetate;
pH=7;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxygen; triethylamine / copper diacetate / dichloromethane / 32 h / 20 °C / Molecular sieve
2.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1 h / 85 °C
2.2: pH 7
With
water; oxygen; triethylamine; potassium hydroxide; tert-butyl XPhos;
tris-(dibenzylideneacetone)dipalladium(0); copper diacetate;
In
1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxygen; triethylamine / copper diacetate / dichloromethane / 32 h / 20 °C / Molecular sieve
2.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1 h / 85 °C
2.2: pH 7
With
water; oxygen; triethylamine; potassium hydroxide; tert-butyl XPhos;
tris-(dibenzylideneacetone)dipalladium(0); copper diacetate;
In
1,4-dioxane; dichloromethane;
![4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indole-6-carbonitrile](/Databaselist/images/loading.webp)
