(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone

Base Information

• Chemical Name: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone
• CAS No.: 1285572-51-1
• Molecular Formula: C₁₄H₉Cl₂NO₄S
• Molecular Weight: 358.202

Synonyms:(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone

Chemical Property of (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone

Chemical Property:

• Melting Point: 188 - 191°C
• Boiling Point: 614.8±55.0 °C(Predicted)
• Density: 1.662±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Dotinurad 98.10% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Uses: Dotinurad is a useful drug for treating hyperuricemia and gout.

Technology Process of (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone

There total 10 articles about (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

2,3-dihydro-1,1-dioxobenzothiazole (4433-53-8) + 3,5-dichloro-4-hydroxybenzoic acid (3336-41-2) → (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ6-1,3-benzothiazol-3-yl)methanone (1285572-51-1)

Guidance literature:

3,5-dichloro-4-hydroxybenzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 - 70 ℃; for 12h; Inert atmosphere;

2,3-dihydro-1,1-dioxobenzothiazole; In acetonitrile; for 12h; Inert atmosphere;

Reference yield: 85.2%

(3,5-dichloro-4-hydroxyphenyl)-(3-(2H)-benzothiazolyl)methanone (1285572-54-4) → (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ6-1,3-benzothiazol-3-yl)methanone (1285572-51-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 - 35 ℃; for 16h;

Reference yield: 77.8%

3-(3,5-dichloro-4-methoxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole (1285573-44-5) → (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ6-1,3-benzothiazol-3-yl)methanone (1285572-51-1)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 130 ℃; for 2h;

DOI:10.1021/acsmedchemlett.0c00176

upstream raw materials:

2,3-dihydro-benzothiazole

3,5-dichloro-4-methoxybenzoic acid

2-amino-benzenethiol

3,5-Dichloro-4-methoxybenzoyl chloride

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