7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Base Information

Chemical Name:7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine
CAS No.:1585145-64-7
Molecular Formula:C₂₈H₂₉F₂N₅O₂
Molecular Weight:505.567
Hs Code.:

Synonyms:7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

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Chemical Property of 7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

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Technology Process of 7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

There total 10 articles about 7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197333-44-0
5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-ylamine

: 1585145-82-9
3-chloro-7-(2,6-difluoro-3,5-dimethoxyphenyl)isoqinoline

: 1585145-64-7
7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In toluene; tert-butyl alcohol; at 120 ℃; Inert atmosphere;

Reference yield:

: 1585145-79-4
[5-(4-methylpiperazin-1-ylmethyl)pyridin-2-yl]carbamic acid tert-butyl ester

: 1585145-64-7
7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; toluene; tert-butyl alcohol;

Reference yield:

: 169280-82-4
6-((tert-butoxycarbonyl)amino)nicotinic acid ethyl ester

: 1585145-64-7
7-(2,6-difluoro-3,5-dimethoxyphenyl)-N-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 6 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile; tert-butyl alcohol;