(R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt

Base Information

• Chemical Name: (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt
• CAS No.: 947370-34-5
• Molecular Formula: C₈H₁₇N*C₃₅H₃₆ClNO₃S
• Molecular Weight: 713.424
• Mol file: 947370-34-5.mol

Synonyms:(R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt

Chemical Property of (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt

There total 4 articles about (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt (947370-34-5)

Guidance literature:

Reference yield: 94.0%

cyclooctylamine (5452-37-9) + montelukast (158966-92-8) → (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt (947370-34-5)

Guidance literature:

In toluene; at 25 ℃; for 1h; Heating / reflux;

Reference yield:

cyclooctylamine (5452-37-9) + 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol (807638-71-7) + 1-(sulfanylmethyl)cyclopropaneacetic acid (162515-68-6) → (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid cyclooctylammonium salt (947370-34-5) + (R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-methylethenyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid cyclooctylammonium salt

Guidance literature:

1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃;

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 3h;

cyclooctylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; toluene; for 1.5h; Product distribution / selectivity;

upstream raw materials:

cyclooctylamine

montelukast

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

1-(sulfanylmethyl)cyclopropaneacetic acid

Downstream raw materials:

montelukast

Montelukast sodium

(R-(E))-1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-methylethenyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid sodium salt