4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

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Chemical Name:4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester
CAS No.:932725-87-6
Molecular Formula:C₂₈H₃₇ClF₂N₃O₁₀P
Molecular Weight:680.039
Hs Code.:

Synonyms:4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

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Chemical Property of 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

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Technology Process of 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

There total 9 articles about 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880596-70-3
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

: 39895-10-8,84907-98-2
L-aspartic acid β-tert-butyl ester α-methyl ester

: 932725-87-6
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm061146x

Reference yield:

: C₁₀H₉Cl₂F₂O₃P

: 932725-87-6
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

3.1: 69 percent / Me₃SnOH / 1,2-dichloro-ethane / 3 h / Heating

4.1: 0.32 g / PyBOP; DIEA / CH₂Cl₂ / 1 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trimethyltin(IV) hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm061146x

Reference yield:

: 932725-73-0
methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate

: 932725-87-6
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: CH₂Cl₂ / 18 h

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

3.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

4.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

5.1: 69 percent / Me₃SnOH / 1,2-dichloro-ethane / 3 h / Heating

6.1: 0.32 g / PyBOP; DIEA / CH₂Cl₂ / 1 h / 0 - 20 °C

With oxalyl dichloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trimethyltin(IV) hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm061146x