4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

Base Information

Chemical Name:4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid
CAS No.:880596-70-3
Molecular Formula:C₁₉H₂₂ClF₂N₂O₇P
Molecular Weight:494.816
Hs Code.:

Synonyms:4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

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Chemical Property of 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

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Technology Process of 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

There total 8 articles about 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 880596-26-9
methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

: 880596-70-3
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

Guidance literature:: methyl 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate; With lithium hydroxide; water; In tetrahydrofuran; at 0 ℃;

With water; citric acid; In tetrahydrofuran;

Reference yield: 67.0%

: C₃₃H₃₂ClF₂N₂O₇P

: 880596-70-3
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

Guidance literature:: C₃₃H₃₂ClF₂N₂O₇P; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.416667h;

With water; ammonium chloride; In dichloromethane;

Reference yield:

: C₁₀H₉Cl₂F₂O₃P

: 880596-70-3
4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C

2.2: 60 percent / tetrahydrofuran / 10 h / -78 °C

3.1: 69 percent / Me₃SnOH / 1,2-dichloro-ethane / 3 h / Heating

With N-ethyl-N,N-diisopropylamine; trimethyltin(IV) hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm061146x