methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Base Information

• Chemical Name: methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate
• CAS No.: 880595-47-1
• Molecular Formula: C₁₅H₂₀Cl₂F₂NO₃P
• Molecular Weight: 402.205
• Mol file: 880595-47-1.mol

Synonyms:methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Chemical Property of methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate

There total 5 articles about methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H9Cl2F2O3P + N-methyl-N-(4-chloro-n-butyl)amine hydrochloride → methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate (880595-47-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 ℃; for 20h;

DOI:10.1021/jm061146x

Reference yield:

methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate (932725-73-0) → methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate (880595-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 18 h

2: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

3: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm061146x

Reference yield:

C16H27F2O5PSi2 → methyl 4-[chloro-N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetate (880595-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 1.5 h

2: 2.54 g / diisopropylethylamine / CH₂Cl₂ / 20 h / -20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm061146x

upstream raw materials:

methyl 4-[diethyl phosphono(difluoromethyl)]phenylacetate

(4-iodophenyl)acetic acid

methyl 4-iodophenylacetate

Downstream raw materials:

C₄₇H₅₉Cl₂F₄N₇O₁₅P₂

4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester

4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester

4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic acid